Disease Areas, Sample Types and Study Designs
Disease Areas
We work across all disease indications, matrices and deliver globally.
To understand capabilities, most collections of 100 or so samples complete in 1 to 3 months, and smaller collections of 10 to 30 samples could be as little as 2 to 4 weeks.
In addition, there are disease areas in which we have developed deeper focuses. These are as follows (the lists are non-exhaustive, so please contact us if you need support in an area outside these):
Oncology
We have significant capabilities in oncology. We can arrange additional testing, and can stratify by stage and cancer features (such as TNBC). Currently, if there was an open request across all cancer types, we could collect over 1,000 cases per month, and ramp up to 2,000 per month if there was a sufficient long-term project.
Solid Tumours
Lung Cancer (NSCLC incl. Adenocarcinoma, SCLC), Colorectal Cancer (incl. MSI-High), Breast Cancer (Invasive Ductal, Lobular, DCIS; by ER, PR and HER2 status, incl. HER2-low and TNBC; ESR1-mutant, BRCA1/2-mutated), Liver Metastases, Uterine / Endometrial Cancer, Oesophageal Cancer, Gastric / GEJ Cancer, Ovarian Cancer (incl. Ascites), Prostate Cancer, Pancreatic Cancer (PDAC), Cervical Cancer, GIST, Testicular Cancer, Bladder / Urothelial Cancer, Renal Cell Carcinoma, Hepatocellular Carcinoma, Biliary Tract Cancer, Melanoma, Head and Neck Cancer, Small Intestine Cancer, Mesothelioma, Thyroid Cancer (incl. Papillary), Anal Cancer, Vulvar Cancer, Basal Cell Carcinoma (BCC), Cutaneous Squamous Cell Carcinoma (SCC), Fallopian Tube Cancer, Peritoneal Cancer, Soft Tissue Sarcoma, Liposarcoma, Metastatic Tumours
Pre-cancerous & Benign
Advanced Adenomas, IPMN, Colorectal Polyps, Benign Tumours (Adenomas, Fibroids), Hyperplasia (e.g. Benign Prostatic, Endometrial)
Haematological Malignancies
Acute Myeloid Leukaemia (AML), Acute Promyelocytic Leukaemia (APL), Non-Hodgkin's Lymphoma (incl. DLBCL, Follicular), Hodgkin's Lymphoma, Multiple Myeloma, Acute Lymphoblastic Leukaemia (ALL), Chronic Lymphocytic Leukaemia (CLL), Chronic Myeloid Leukaemia (CML), Myelodysplastic Syndromes (MDS), Myeloproliferative Neoplasms (MPN)
Immunology, Autoimmune & Dermatology
Dermatology
Hidradenitis Suppurativa, Psoriasis (incl. Plaque Psoriasis), Atopic Dermatitis, Vitiligo, Lichen Simplex Chronicus, Alopecia Areata, Chronic Urticaria, Keloid, Diabetic Foot Ulcer, Acne Vulgaris, Rosacea, Seborrhoeic Dermatitis, Contact Dermatitis / Hand Eczema, Lichen Planus, Actinic Keratosis
Rheumatic & Systemic Autoimmune
Rheumatoid Arthritis (RA), Psoriatic Arthritis, Systemic Lupus Erythematosus (SLE), Sjögren's Syndrome, Systemic Sclerosis (Scleroderma), Behçet's Disease, Axial Spondyloarthritis / Ankylosing Spondylitis, Hashimoto's Thyroiditis, Polymyalgia Rheumatica, Gout, Graves' Disease
Infectious Diseases
Respiratory Infections
Influenza (A/B), COVID-19, RSV and Respiratory Panels, Tuberculosis, Strep Throat, Community-acquired Pneumonia
Blood-borne Viruses & Hepatitis
HIV (incl. HIV-2), Hepatitis B (incl. HBsAg), Hepatitis A, Hepatitis D / E, Hepatitis C, Cytomegalovirus (CMV), Epstein–Barr Virus (EBV)
Sexually Transmitted, Tropical & Other
Human Papillomavirus (HPV), Herpes Simplex Virus (HSV), Syphilis, Gonorrhoea, Chlamydia, Urinary Tract Infection (UTI), Herpes Zoster (Shingles), Dengue, Chikungunya, Zika Virus, Malaria
Gastrointestinal & Liver Diseases
Inflammatory Bowel Disease & Coeliac
Crohn's Disease, Ulcerative Colitis, Coeliac Disease, Microscopic Colitis
Other Gastrointestinal Conditions
Gastroesophageal Reflux Disease (GERD), Small Intestinal Bacterial Overgrowth (SIBO), Irritable Bowel Syndrome (IBS), Gastritis (incl. H. pylori) and Peptic Ulcer Disease, Pancreatitis (Acute, Chronic), Diverticulitis, Barrett's Oesophagus, Eosinophilic Oesophagitis, Gallstone Disease / Cholecystitis, Appendicitis, Functional Dyspepsia, Chronic Constipation, Haemorrhoids
Liver
Liver Cirrhosis, MASLD / MASH (NAFLD / NASH), Drug-Induced Liver Injury (DILI), Liver Fibrosis (staged), Alcohol-related Liver Disease, Portal Hypertension / Oesophageal Varices
Neurology
Neurodegenerative
Alzheimer's Disease (incl. MCI, by severity), Dementias (incl. Frontotemporal Dementia), Parkinson's Disease, Multiple System Atrophy, Huntington's Disease, Amyotrophic Lateral Sclerosis (ALS / MND)
Other Neurological & Psychiatric
Multiple Sclerosis (MS), Epilepsy, Schizophrenia, Stroke, Migraine, Peripheral Neuropathy, Essential Tremor, Major Depressive Disorder, Bipolar Disorder
Respiratory Diseases
Airways Disease
Chronic Obstructive Pulmonary Disease (COPD), Bronchiectasis (NCFB), Asthma, Cystic Fibrosis, Chronic Sinusitis, Allergic Rhinitis
Interstitial & Other Lung Conditions
Idiopathic Pulmonary Fibrosis (IPF), Interstitial Lung Disease (ILD), Lung Nodules (Benign / Indeterminate), Obstructive Sleep Apnoea, Sarcoidosis
Reproductive & Women's Health
Gynaecology & Fertility
Endometriosis, Polycystic Ovary Syndrome (PCOS), Infertility (Male, Female; incl. Sperm), Menopause, Adenomyosis, Heavy Menstrual Bleeding
Pregnancy & Maternal Health
Pregnancy (by Trimester), Cord Blood / Umbilical Serum, Amniotic Fluid, Pre-eclampsia, Gestational Diabetes, Preterm Birth, Recurrent Pregnancy Loss
Endocrine, Metabolic & Cardiovascular
Diabetes & Metabolic
Type 2 Diabetes, Type 1 Diabetes, Diabetic Neuropathy, Obesity (incl. Severe / Clinical Obesity), Metabolic Syndrome, Prediabetes, Dyslipidaemia / Hypercholesterolaemia, Diabetic Retinopathy
Endocrine & Bone
Thyroid Disorders (Hypothyroidism, Hyperthyroidism, Thyroid Nodules), Osteoporosis and Bone Metabolism Disorders, Vitamin D Deficiency
Cardiovascular
Hypertension, Cardiomyopathies (Dilated, Hypertrophic, Arrhythmogenic), Coronary Artery Disease, Myocardial Infarction, Congestive Heart Failure, Atrial Fibrillation and Arrhythmias, Atherosclerosis and Peripheral Artery Disease (PAD), Pulmonary Embolism (PE), Vascular Disorders (Carotid Artery Disease, Aneurysms), Deep Vein Thrombosis (DVT), Valvular Heart Disease / Aortic Stenosis
Specialist Areas
Ophthalmology
Aqueous Humour, Cataract, Glaucoma, Age-related Macular Degeneration (AMD), Diabetic Macular Oedema, Dry Eye Disease
Renal
Chronic Kidney Disease (CKD), Glomerular Diseases (incl. IgA Nephropathy), Dialysis / End-stage Renal Disease, Diabetic Kidney Disease, Acute Kidney Injury, Kidney Stones
Allergy
Severe Anaphylaxis (High Tryptase), Allergies, Food Allergy, Drug Allergy
Critical Care & Trauma
Severe Trauma (incl. Polytrauma), Traumatic Brain Injury (TBI), Sepsis, Burns, Acute Respiratory Distress Syndrome (ARDS)
Non-indicated / Healthy Control
Adult Donors
Healthy Volunteers, Screen-negative / Colonoscopy-checked Donors, Plastic Surgery Donors, Smokers / Ex-smokers (no diagnosed disease), High-risk Asymptomatic (e.g. Family History)
Life Stage
Healthy Pregnant Women (by Trimester), Neonates, Children (Paediatric), Elderly (65+)
Biosample Types
Blood and Derivatives
- Whole Blood
- Serum
- Plasma (Single-, Double-, Triple-spun)
- Anticoagulants / tubes: EDTA, Citrate, Heparin, Streck, PAXgene, LBGard, etc.
- Buffy Coat
- PBMCs
- Bone Marrow Aspirate
- Dried Blood Spot (incl. Capillary Devices)
- Cord Blood
Resection and Biopsy Tissue
- Tumour Tissue
- Normal Adjacent Tissue
- Metastatic Tissue
- Endoscopic Mucosal Biopsies (Lesional, Non-lesional)
- Skin Punch Biopsies (Lesional, Non-lesional)
- Gynaecological & Obstetric Tissue (Endometrium, Ovarian, Peritoneal, Placenta)
- Healthy Skin Tissue
- Subcutaneous Adipose Tissue
- Post Mortem Tissues
Other Biofluids and Sample Types
- Aqueous Humour
- Cerebrospinal Fluid (CSF)
- Urine
- Stool / Faecal
- Saliva
- Swabs (incl. VTM, Cervical)
- Induced Sputum
- Peritoneal Fluid / Lavage
- Bronchoalveolar Lavage (BAL)
- Bile
- Ascitic Fluid
- Synovial Fluid
- Exudates
- Tears
- Amniotic Fluid
- Semen
- Hair
Preservation and Shipment Formats
- Chilled (24 to 48 hours shipment)
- Ambient
- Frozen (-20°C, -80°C, LN2)
- Snap-frozen Tissue
- RNAlater-preserved Tissue
- Formalin-Fixed, Paraffin-Embedded (FFPE: Blocks, Slides, Curls)
Study Designs
Extant ethics, and ICFs in place allowing immediate study start and appropriate broad use in commercial life sciences, and we can obtain ethics amendments or new approvals where a study requires them.
Access to sites that follow ESMO and other European clinical guidelines, with consistent reimbursement and treatment schedules, and access to electronic health records (EHR).
Fresh Sample Studies
Samples shipped on the day of collection to laboratories across Europe and North America, arriving within 24 to 48 hours. Suited to studies needing fresh material such as whole blood or tissue, available across most indications.
Stratified Cohorts
By disease stage, subtype and molecular features (e.g. TNBC, HER2-low, MSI-High, ESR1-mutant), treatment status and line of therapy (e.g. CDK4/6 inhibitors, checkpoint inhibitors, anti-HER2), and demographics.
Matched & Multi-matrix Samples
Tumour, normal adjacent tissue and blood from the same donor; FFPE with matched plasma; plasma with matched buffy coat; multiple sample types from one donor (e.g. blood, urine and stool).
Longitudinal, Recall & Follow-up
Serial timepoints and multi-visit studies; pre- and post-treatment sampling; recall of donors for repeat sampling; long-term data follow-up (e.g. recurrence, survival and outcomes).
Controls & Family Studies
Healthy controls matched by age, sex, BMI and co-morbidity; screen-negative / colonoscopy-checked controls; family studies, including first-degree relatives.
Your Protocols
Highly customised collection when required: client kits or kits we build, client processing protocols, and sourcing of specific tube types and storage reagents. We can also arrange additional testing, and run a pilot phase for feedback before the main collection.
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